Abstract

To examine the association between low testosterone activity & low blood pressure through the change in lipid profile parameters. A case control study. At al-batool infertility clinic in Mosul, during the period from October 2006-April 2007. One hundred four infertile men ,aged 20-70 years divided into two groups, group one consisted of 67 infertile men without replacement therapy. Group two, included 37 infertile men with replacement therapy. 100 men were apparently healthy, fertile, normotensive, attending outpatient clinic used as a control group. They were investigated by measuring serum triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) & very low density lipoprotein (VLDL), by using enzymatic colorimetric method. The blood pressure, body mass index measurement were done. Serum testosterone measurement was also done using ELISA. 47.2% of infertile men showed a decline in serum testosterone below normal level.42.3% showed high blood pressure above normal. There was a significant decrease in serum testosterone & HDL in group one as compared with control group, while they exhibit a significant increase in diastolic blood pressure, TC, LDL & atherogenic index. A significant negative correlation between testosterone & each of diastolic blood pressure, BMI, was noted. Also there was a significant positive relationship between testosterone & HDL concentration. This finding of positive correlation between testosterone & HDL are consistent with hypothesis that endogenous androgen has a vascular protective influence in men.

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