EFFECT OF PURE LIGNAN FROM FLAXSEEDS (LINUM USITATISSIMUM) ON INDUCED AND ANTIMUTAGENIC ON BACTERIAL SYSTEM

Abstract

The study aimed to compare pure lignan compound with methotraxete (MTX) drug on three bacterial isolates (Bacillus ssp-.(G3), Arthrobacter spp-(G12) and Brevibacterium spp. (G27)). In addition, mutagen (MTX) was compared a standard mutagen which called (NTG). The mutagen MTX has higher mutation effect than NTG on the bacterial isolates. The lignan compound showed no effect at 50 and 75 g/ml concentrations but at 100 g/ml of lignan was caused the mutagen resistance to streptomycin for treated isolates 383.3, 166.6 and 166.6 mutation/ml for G3 , G12 and G3 isolates respectively. This means the lignan concentrations have the inhibition effect on bacterial isolates which result in dead ratio ranged between 1.9– 54 % on the G3 isolates.