Attenuated LaSota Virus Vaccine with a Urtica Pilulifera Extract In Treatment of Mammary adenocarcinoma in Mice

Abstract

background: The attenuated Newcastle Disease Virus (NDV) vaccine LaSota strain has been foundto cause regression in volume of mammary adenocarcinoma transplanted subcutaneously in micewhen injection locally (intratumoral) with Urtica pilulifera orally. The growth inhibition at theend of experiment was (77%) and statistically significant compared with the tumor volume inuntreated group. While the growth inhibition in the group treated intraperitonealy (I.P) was (28%).Therelative tumor volume was decreased in the group treated with virus (I.T) but increased in grouptreated (I.P) comparing with the tumor size at the begining of treatment. Histopathologically , there wasan extensive area of necrosis and replacement by granulation tissue with mononuclear cellsinfiltration (lymphocytes, plasma cells and macrophages).