STUDY OF THE RELATIONSHIP OF CagA TOXIN AND IT'S PHOSPHORYLATION SITES WITH THE OUTPUT OF DIFFERENT STRAINS OF Helicobacter pylori INFECTIONS

Abstract

ABSTRACTHelicobacter pylori causes different digestive system diseases. H.pylori hasdifferent virulence factors, among them CagA which is phosphorylated at tyrosineresidue located in special motif of five amino acid "EPIYA". CagA toxin may havedifferent number and EPIYS(s). Relationship between the CagA(s) with EPIYA orwithout and diseases in different countries was used by using the sequences inpublic databases. The analyses revealed that there is positive correlation betweenincreasing number of EPIYA(s) and different ulcers; the correlation coefficient rreached +0.866 in peptic ulcer. The relation of EPIYA(s) number and cancer(s)showed inverse relationship as well with gastritis and unknown diseases and rvalues were negative (-0.421,-0.537respectively). It has been concluded thatpresence of motifs and their phospharylation sites are not the chief reasons fordisease induction such as cancer