Susceptibility of Trichophyton mentagrophytes Against Two Antifungals: Griseofulvin and Terbinafine.


After conventional diagnosis, laboratory experiments were done to assess the effect of griseofulvin and terbinafine on the growth of three isolates of Trichophyton mentagrophytes which belong to the genus Trichophyton using agar dilution method. Statistically, results of this study revealed significant difference between the effect of terbinafine and that of griseofulvin both against growth of T.mentagrophytes isolates where the tested fungi were resistant to griseofulvin in spite of increasing the used concentration and giving means of diameters 21.00 mm and 19.33 mm under effects of 5µg and 60µg concentrations respectively while it revealed more response to terbinafine giving means of diameters 10.6 mm and 0.0 mm under effect of 0.25µg and 2µg respectively.The mean of colony diameter for each concentration of griseofulvin was still same statistically showing no decrease while in case of terbinafine ,the mean of colony diameter differ according to each concentration reaching to complete inhibition.