Immunohistochemical expression of P53, as a marker of apoptosis in Hodgkin’s and Non Hodgkin’s lymphoma of the head and neck region


Background: Malignant lymphomas represent about 5% of all malignancy of the head and neck region which caninvolve lymph nodes as well as soft tissue and bone of the maxillofacial region. Apoptosis is considered a vitalcomponent of various processes including normal cell turnover, proper development and functioning of the immunesystem. Inappropriate apoptosis is a factor in many human conditions including neurodegenerative diseases,ischemic damage, autoimmune disorders and many types of cancer. Expression of p53 Proteins in Hodgkin ׳s and NonHodgkin ׳s lymphomas suggested that it can help in monitoring of patients and the markers may aid in controlling theprogression of lymphoma and detect the degree of aggressiveness of the disease to give suitable treatment andmanagement of patients.Material and methods: Sixty seven formalin-fixed, paraffin-embedded tissue, histopathologically diagnosedlymphoma blocks (head and neck lesions) as (24) Hodgkin’s Lymphoma and (43) Non Hodgkin’s Lymphoma.Immunohistochemical (IHC) technique was used for the evaluation of P53 monoclonal antibodies expression andcorrelated with the clinicopathological parameters.Results: The mean of expression of P53 in relation to tumor grades was different as it had a value of (51.2±13.5) in lowgrade tumors, (55.7±20) in the intermediate grade tumor and (45±17.6) in high grade tumors; consequently, thisdifference did not reached the level of statistical significance P(ANOVA) >0.05.Conclusions: This study had shown that there was no significant correlation between the mean of expression of P53 inHL and NHL