Synthesis of Prodrug Polymer as Ring Opening of PVP


In this work a new drug polymer was prepared from reaction of polyvinylpyrrolidone (PVP) with doxycylin in 10:1 dioxane: dimethelyformad solvent mixture. The prepared drug polymer was formed with 85% conversion percentage. The physical properties were studied and intrinsic viscosity was equal to 0.23 dl/g. The drug polymer was characterized by FT-IR and UV spectroscopy. The swelling % was studied in different non solvents. The elemental analysis and DSC were analyzed. The controlled release rates for drug polymer were studied in different pH values at 37oC for 4 days. The softening point of the prepared doxycyclin drug polymer was 143.4oC to 150.3oC with ΔH=-189.89 J/g.