Histopathological Assessment of Anti-Ulcerogenic Effect of Montelukast Against Acetyl Salicylic Acid Induced Gastric Ulcer in Male Rabbits

Abstract

The effects of anti-ulcerogenic drugs are dependent on the increase in prostaglandin production and reduction in leukotriene production in the gastric mucosa. This study aimed to evaluate the gastro-protective effect of montelukast both macroscopically and microscopically .Thirty local domestic male rabbits had been used in this study, divided randomly into 5 groups as follows: control group, acetylsalicylic acid (ASA) group, Omeprazole group, montelukast group and montelukast alone group. At the end of the experiment, the stomachs of rabbits were removed then the mucosa was examined to determine the ulcer parameters by means of dissecting microscope. Furthermore, stomach tissue sections were prepared for histological examination. The results of this study revealed as aministration of acetyl salicylic acid in dose of 500 mg/kg significantly increased the mean ulcer index and showed necrosis of gastric mucosa associated with submucosal edema and inflammatory cell infiltrate. But in presence of montelukast significantly decreased the ulcer index with antiulcerogenic activity about 81%, mild edema and inflammatory cell infiltration. In this study, it was observed that montelukast behaved as an anti-ulcerogenic drug both macroscopically and microscopically.