Synthesis & Characterization of Some 1, 3, 4-OxadiazoleDerivatives & new Cyclic Imides from Creatinine


A series of new 1,3,4- oxadiazole derivatives and cyclic Imides containing Creatinine heterocyclic molecule were prepared via following method:first step included Synthesis of amic acid from reaction between different cyclic anhydrides with Creatinine which subsequently dehydrated to the corresponding imide via treatment with acetic anhydride and anhydrous sodium acetate,.then,second step was trated amic acid with Thionyl chloride producing acid chloride which on amination with hydrazine hydrate in thierd step and the last turn to 1,3,4-oxadiazole derivatives by condensation reaction with Phosphorous Oxychloride(POCl3) and different benzoic acids. Cyclization to 1, 3, 4-Oxadiazole derivatives. Antibacterial activity of some prepared new compounds against two types of bacteria were evaluated and result showed the new exhibit good moderate antibacterial activity.Prepared compounds were elucidated on the basis FT-IR,1H-NMR and MASS spectro data which agreed with the proposed structures