Evaluation the effect of NB–UVB phototherapy on thyroid function in sera of vitiligo patients


AbstractBackground: Vitiligo is a relatively common dermatologic finding observed since ancient times. The cause of this disease is unknown yet. Narrow-band ultraviolet B (NB-UVB) is an emerging, promising phototherapy for vitiligo. Methods: A total of 31 patients with vitiligo and 32 control subjects were the participant of the present study. Vitiligo patients were received NB-UVB treatment for three days weekly. T3, T4 and TSH were assayed in each sample using radioimmunoassay technique. Results: There was a significant difference in T3 level in the patients with vitiligo before treatment compared with its level in the control group (P=0.018), but no significant differences were found in T4 and TSH levels. When the comparison of these parameters levels were done according the gender within each group, no significant difference was observed. The results of the treatment on the measured hormones indicated that this type of treatment has no effect on the level of T3, T4 and TSH in vitiligo patients. Conclusion: On the bases of current study results, NB-UVB seems to be considered as a suitable therapeutic treatment of vitiligo as far as on thyroid function.


Vitiligo, NB-UVB, T3, T4, TSH.