Synthesis and cytotoxic activity study of 3-(2,4-dichlorophenyl)-1-(4'-methoxyphenyl)-3-hydroxypropan-1-one

Abstract

A new methodology was used to synthesis -hydroxyketone compound namly 3-(2,4-dichlorophenyl)-1-(4'-methoxyphenyl)-3-hydroxypropan-1-one directly from -unsaturated compound (p-methoxychalcone) in basic medium. Elemental analysis show good agreement between measured and calculated percentage. FT-IR and NMR Spectra techniques were used to identify structure of prepared compound. Minimum inhibitory concentration(MIC) and cytotoxic activity were investigated. The new compound have a limited ability to inhibit microorganisms but have significant cytotoxicity,