Correlation between some immunological parameters and clinicalpresentation in RA patients

Abstract

Background: Complement (C) & CRP in patients with Rheumatoid arthritis
(RA)'could be trigger disease activity.
Aim: To study the correlation between C, CRP, IgM,, IgG, IgA & some clinical
presentation in RA patients.
Methods: Latex agglutination test(AG) & single radial immunoassay(SRIA) were
used to asses CRP, IgMJgGJgA,, C, in 74 patients with RA.
Results: IgA & IgG were significantly increased, while the mean ofC3, C4 were
slightly elevated in RA patients .
Conclusion: There is correlation between IgG and IgM with joint deformity and joint
swelling respectively, while C3 was showed statistically significant P<0.01 with joint
stiffness, joint swelling and Rheumatoid nodule, where as CRP was statistically
significant P<0.01withjoint swelling.. Key words : RA.C.CRP, IgM, IgG, IgA, SRI A,
AG.

Introduction:

Rheumatoid arthritis (RA) is one of the
mysterious autoimmune diseases which is still
unresolved characterized by inflammation of
synovial membrane, principally affecting
peripheral joints in a symmetric fashion,
commonly leads to cartilage destruction, bone
erosion and joint deformities; extra-articular
manifestations such as vasculitis and
subcutaneous nodules can also occur, hence
it's course is quite variable (1 -3).