A Comparative Study of Hematological,Renaland Liver Function Criteria in Type I and Type II Diabetes Mellitus


Diabetes mellitus (DM) is a metabolic syndrome resulting from a deficiency in insulin secretion leading to disorders of carbohydrate metabolism.Two distinguish types of DM are found (type I; insulin dependent, and type II; insulin independent).The chronic, long period complications of diabetes, associate withvascular diseases and dysfunction of kidney and liver.The current study was considered to comparebetweentype I and type II Diabetes Mellitus (DM) and healthy adults insomehematological and biochemicalcriteria.The study was carried out at laboratories of Merjan Hospital and involved 80Diabetic patients (33 type I diabetes mellitus; 14 males and 19 females, and 47 type II diabetes mellitus; 19 males and 28 females) aged between 30-65 years and 35 healthy subjects (10 males and 25 females) aged between 33-60 years.The study included three groups; healthy subjects, type I DM and type II DM.Hematological criteria including red blood cell count (RBC), hemoglobin concentration (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC),red cell distribution width (RDW), white blood cell count (WBC), platelet count (PLT) and mean platelet volume (MPV) were determined by using hemato-analyzer.Serum glucose, serum urea and serum creatinine were measured.Additionally the liver enzymes Glutamic pyruvate Transaminase (GPT) and Glutamic Oxalatetransaminase (GOT) were obtained.The results of this study revealed significant differences (p<0.01) in serum glucose concentration, MCH (in males), RDW (in females) and MPV between the three groups involving in the study. Significant differences (p<0.05) in MCV, RDW (in males), MCHC (in females), serum creatinine, S.GPT and S.GOT within the three groups of the study.Diabetes mellitus is a high prevalent metabolic disease resulting in many health complications. RDW and MPV represent appropriate indicator for vascular complication due to DM.Serum creatinine is more sensitive test for renal dysfunction rather than serum urea in diabetic patients.Elevation in liver enzyme (GPT and GOT) levels is higher in type II DM as compared with type I DM. Hence non-insulin diabetic patient should be examine annually