DETECTION OF AUTO-ANTIBODIES SPECIFIC TO ISLETS CELLS INPATIENTSWITH THYROID DYSFUNCTION BY USING BIOCHIPSTECHNIQUE

Abstract

Abstract
The aim of this study was to detect the auto immune Type 1 diabetes among the disorders with
thyroid dysfunction (hyperthyroidism and hypothyroidism).The study included 50 patients suffering
from thyroid dysfunction, their aged was from (1-30) years. They were selected randomly from the
Al-kindy center for infertility and indocrinology. The control group consisted of (20) healthy
subjects comparable for age and sex of study groups. Thyroid function tests (thyroid-stimulating
hormone [TSH], thyroxin, and triiodothyronine) measured in by using miniVIDAS system and
auto-antibodies for Beta cells in pancreas estimated in the same patients by using
immunofluorescent method (IFAT), the method named BIOCHIPS Mosaic. Results of thyroid
function test revealed that 25 patients were evaluated to have hyperthyroidism and 25 patients with
hypothyroidism and the results of BIOCHIPS showed hyperthyroidism group was having autoantibodies
specific to islets cells with 8 percent of all the subjects (two from 25 patients) .While
there was no signs of auto antibodies for islets cells in hypothyroidism group. The study revealed
that the prevalence of thyroid dysfunction was higher in women than men.