Some Histological Effects of Panadol Extra on Albino Mice Liver

Abstract

The present study was aimed to investigate the effect of panadol extra drug in induction of lesions on the liver tissues of male albino mice. Experiment was done in the laboratories of the state company for drugs industry and medical applications, Samarra-Iraq (SDI), and continued from march (2015) to July (2015), thirty male mice with age (8-10) weeks and (23-27) gm of weight were distributed into six groups, each group included five male mice.The result showed high significant increase (P < 0.01) in the liver weight of animals treated with panadol extra drug compared with control group. Microscopic examination showed a histological lesions present in the liver of treated groups represented by necrosis, degeneration and disorganization of the hepatocytes columns towards the central vein, wall thickening of central veins and hepatic arteries with congestion, bile duct surrounded by fibers and infiltration of lymphocytes and neutrophils compared with control group