HYPERTENSION AND OBESITY IN RELATION TO HIGH SENSITIVITYC-REACTIVE PROTEIN AND LIPID PROFILE IN IRAQI PATIENTS

Abstract

Abstract
Introduction:
High sensitive C-reactive protein (hs-CRP) is one of new inflammatory markers which has been
proposed as independent risk factor for cardiovascular disease, and it is positively associated with
body weight. Little is known, however, about the utility of (hs-CRP) and other biomarkers in obese
hypertensive Iraqi patients.
Objectives:
To examine the hypothesis that there is a relation between obesity, hypertension and a chronic
low-grade inflammatory status (represented by high hs-CRP).
Patients and Method:
A total number of 99 patients stratified according to hypertension and obesity into two groups:
1. Obese hypertensive: Body mass index (BMI > 30 kg/m2 and blood pressure (BP) >140/90 mmHg
± history of taking anti hypertensive medications), n = 65, Age = (56.02 ± 4.379) years,
BMI = (35.68 ± 4.78) kg/m².
2. Over weight normotensive: (BMI > 25 kg/m² and < 30 kg/m2, BP < 140/90 mmHg), n = 34,
Age = (56.44 ± 3.17) years, BMI = (26.06 ± 3.05) kg/m².
Assessment of (hs-CRP) and lipid profile (total serum cholesterol (s.chol), serum triglyceride
(s.TG), low density lipoprotein (LDL), and high density lipoprotein (HDL) was done.
Results:
The (Mean ± SD) of (hs-CRP) in the patients and controls were (5.74 ±2.15) mg/l and
(2.14 ± 0.85) mg/1 respectively, (P < 0.001). The (Mean ± SD) of cholesterol for cases and control
were (215.17 ± 33.3) mg/dl and (197.81 ± 27.3) mg/dl respectively, (P < 0.05). For HDL were (51.31 ±
7.45) mg/dl and (54.63 ± 5.091) mg/dl respectively, (P < 0.05). For LDL were (136.9 ± 32.87) mg/dl and
(117.81 ± 24.73) mg/dl respectively, (P < 0.005). For BMI were (35.68 ± 4.78) kg/m2 and
(26.06 ± 3.05) kg/m2 respectively, (P < 0.001).
Conclusions:
There is an elevation of serum level of (hs-CRP) in hypertensive obese subject in comparison with low
levels in control group