The Frequency of Epstein-Barr Virus Infection As A Pathogenic Agent In Laryngeal Carcinoma of Iraqi Patients Demonstrated By LMP-1 Expression


The frequency of Epstein-Barr Virus (EBV) antigen; latent membrane protein-1 (LMP-1) expression in cases of laryngeal carcinomas was investigated by immunohistochemical staining technique. Fifty-six cases were included in this work; all cases of laryngeal carcinomas were squamous cell carcinomas with different degrees of differentiation. Immunohistochemical staining results revealed 60.7% positive staining results in overall cases, distributed according to the degree of differentiation almost equally (60% in well differentiated, 64.5% in moderately differentiated and 60% in poorly differentiated). The concordance of cigarette smoking with LMP-1 expression was high (96%). These results indicate the highly possible oncogenic effect of EBV infection on the development of laryngeal carcinomas in Iraqi patients.