Study some Immunological paramrters in some infected patients with typhoid fever in diaylia governorate

Abstract

The study aimed to evaluate some immunoglobulins for some infected patients with typhoid fever, in Diyala governorate. In which 74 blood samples were collected from patients with typhoid fever as well as (40) sample collected from apparently healthy individuals has been accredited as a control group and the study, has continued during the period between September 2012 and up to May of 2013. From 74 sample the results of the study had showed that of the total (74) sample that there is a rise in the proportion of the level three immunoglobulin (IgG, IgM,IgA) for patients compared to control the mean of the (IgG)was (1743 .228 mg / dl) in patients group compared to control (1093.120 mg/dl) and The mean of IgM was (212.605mg/dl) in patients group compared to control(147.640 mg/d ) and the mean of IgA was (276.259 mg / dl) in the patients group compared to the control group (142.118mg/dl) .Also the Study aimed to Measure the complement factors (C3,C4) by using the single radial immunoassay diffusion method in patients with typhoid fever where the results of the study a high level of C3 in a group of patients was increase (109.019 mg / dl) compared to control group ( 108.475mg / dl), and this is an evidence the innate immune response in patients represented by the complement system were stimulated in patient group. and, results of the study also showed a low level of complement (C4) in a group of patients and at a rate (31.627mg/dl) compared to the control group (34.715mg/dl) this is an evidence that the patient immunity had affected in response to infection. From the above , the results of the study had revealed that both the Humoral immunity (IgG,IgM,igA) and Innate immunity were effected in patients with typhoid fever