Evaluation of Homocysteine Level in Type II Diabetes Mellitus and Relationship to Body Weight

Abstract

Type II diabetes mellitus includes group of various metabolic disorders (for carbohydrates, proteins, and fats) and also accompanied by the increase in the level of the abnormal concentration of plasma homocysteine in the blood, leading to higher risk of heart disease and blood vessels.The aim of this study is to assessment the level concentration of plasma homocysteine and vitamin B12 for patients with type II diabetes mellitus and their relationship with other biochemical variables. The study included 54 patients aged (36-80 years) consists of 29 females and 25 males, compared with 26 healthy subjects aged(26-68years) as control group, consists of 14 females and 12 males. It was studying the relationship between diabetic patients group and healthy control group through the study of variables which include the concentration of homocysteine(HCY),vitamin B12, insulin, insulin resistance(HOMA-IR), glucose,B. urea, creatinine, cholesterol (CH), Triglycerides (TG), high density lipoproteins (HDL-ch), low density lipoproteins (LDL-ch), and Very low density lipoproteins (VLDL-ch), and the results have showed the following: Existence high significant elevation at the level of probability (p≤0.001) in Homocystine concentration, level of insulin resistance, and glucose concentration , and presence significant elevation at the level of probability(p≤0.05) in Insulin, LDL-ch, VLDL-ch, Ch, and TG concentrations, and there are significant decline at the level of probability (p≤0.05) in the concentration of B12, for diabetic patients when compared with the healthy group. Existence significant elevation (p ≤ 0.05) in Homocystine, insulin concentration, and level of insulin resistance, and existence significant decline (p ≤ 0.05) in the concentration of B12, in diabetic patients when compared with healthy control group according to body mass index. Existence high reverse significant correlation between homocysteine and B12 in diabetic patients and healthy group, and existence extrusive correlation between Homocysteine and insulin resistance in diabetic patients. And also existence extrusive correlation between homocysteine and age groups in the healthy group , and existence reverse correlation between homocysteine and VLDL-ch, in diabetic patients,