Pathological study on mice intestine experimentally infected with Shiga toxin-producing E. coli O26


Mice infected with STEC O26 (2.5×108 C.F.U/ml) to study the pathological changes in intestine due to infection. The gross pathological changes in the small and large intestine were characterized by variable degrees of hyperemia with engorgement semisolid stool was present in the proximal half and fully formed feces in distal colon. The histopathological changes were characterized by, intestine with all stages of sloughed, eroded and complete necrosis of the villi also diffusion together, necrosis the epithelial cells lining the intestinal glands, diffuse inflammation, and crypt abscesses. Moreover, increase in the goblet cells as well as depletion at late stage. In conclusion, The experimental mice infection with STEC O26 induced a significant pathological changes in intestine