Study of Tryptase Activity and Selenium Concentration in Cardiovascular And Diabetic Patients


Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure (HF). HF represents one of the most common causes of death in patients with DM and results from DM-induced CAD and diabetic cardiomyopathy. selenium concentration and tryptase activity were obtained from 52 samples: 30 sample with cardiovascular and diabetic patients, and 22 normal healthy. A highly significant decrease (p<0.0001) in the levels of selenium, and a significant increase (p<0.05) in the levels of tryptase in serum of patients with cardiovascular and diabetic patients compared with normal individuals. selenium concentration was affected by cardiovascular and diabetic patients and tryptase has higher diagnostic validity values in the current study.