IMMUNOLOGICAL PROFILE IN DIFFERENT GROUPS OF END STAGE RENAL DISEASE

Abstract

Background and aim of study: End Stage Renal Disease (ESRD) is a worldwide problem in which patients are in hemo-dialysis and/or awaiting for kidney transplantation. However, the actual mechanism (s) of ESRD pathogenesis is ill-defined. The aim of this study is to investigate the role of certain immunological markers in the pathogenesis of ESRD. Materials and methods: Sixty eight blood samples were collected from hospitalized ESRD patients with different etiology (hypertensive, diabetics, hypertensive + diabetics, and small size kidney). Twenty healthy volunteers as control group was enrolled in the study. Serum IL-10, IL-17, MCP-1 and TGF-β were estimated in all subjects. Result: A significant elevation in the serum IL-10, MCP-1 and IL-17 mean concentration in all ESRD patients groups. TGF-β mean concentration exhibited decreasing level in the hypertensive, hypertensive + diabetes and small size kidney groups and a slight elevation in the diabetes group. The IL-10: IL-17 ratio expressed elevation in all ESRD patients groups. Conclusion: There is a progress of inflammatory reactions in all ESRD patients groups in which IL-17 and MCP-1 are playing major roles. TGF-β1 is not played its anticipated pro-fibrotic role and anti-inflammatory function in the studied group. The ratio of IL-10: IL-17 point out a slight shifting of the immunosuppressive reaction over the inflammatory reaction in all ESRD patients groups.

Keywords

ESRD, IL-10, IL-17, MCP-1, TGF-β1.