Study The Physiological Changes That Induced by Cadmium Chloride in Male Rat’s and The Role of Sonchus oleraceus Leaves Extract to Treatment

Abstract

The present study was designed to find the physiological changes in male rat’s which were treated with cadmium chloride, then the extract of Sonchus oleraceus leaves was use for treatment to find its role as antioxidant . In this study used 16 male rats that divided randomly to four groups (each group consist of 4 rats), the first group was control group administrated only normal diet and water, the second group administrated with 1mg/kg cadmium chloride for four weeks, the third group administrated with 100 mg/kg leaves extract for 15 days, the fourth group administrated with 1mg/kg cadmium chloride for four weeks and then, treated with 100 mg/kg leaves extract for 15 days. The alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein, urea, creatinine, malondialdehyde (MDA) and catalase levels were showed high significant differences (P< 0.01) in groups that administrated with cadmium chloride compared with control group, but the levels of all parameters back to normal ranges when the groups that administrated with cadmium chloride and treated with Sonchus oleraceus leaves extract. It was concluded that leaves extract has amply good effect on liver , kidneys and Oxidative Stress parameters.