Correlation between Visfatin and Creatine Kinase Levels with Periodontal Health Status of Patients with Coronary Atherosclerosis and Chronic Periodontitis


Background: Visfatin is a novel adipokine that mainly secreted by visceral adipose tissue, had an important role ininflammation and immune system. Creatine Kinase (CK) which is an enzyme that is involved in energy metabolism,found in large amounts in myocardium, brain and skeletal tissues.This study is carried out To evaluate the periodontal health status of the study groups (chronic periodontitis andchronic periodontitis with coronary atherosclerosis) and control groups, to measure the salivary levels of visfatin andCreatine Kinase in these groups and compare between them, and to determine the correlations between salivaryvisfatin and Creatine Kinase levels with the periodontal parameters in the three groups.Materials and Methods: eighty participants, males and females were recruited in this study with age ranged from (30-60) years, they were divided into three groups: the first study group was the Chronic periodontitis group (n=30), thesecond study group was chronic periodontitis and coronary atherosclerosis (n=30) and the control group(n=20)which was healthy systemically with healthy periodontium. Periodontal health status was determined by measuringplaque index(PLI),gingival index (GI), probing pocket depth(PPD), bleeding on probing (BOP) and clinicalattachment level (CAL),salivary samples were taken from each participants, salivary visfatin levels were determinedby enzyme-linked immune-sorbent assay(ELISA) while the activity of salivary Creatine Kinase was determinedspectrometrically by using the International Federation of the Clinical Chemistry (IFCC) method on Hitachi 911Automatic analyzer.Results: The results of the study showed that the mean values of PLI, GI, visfatin, Creatine Kinase and the percentagesof sites according to PPD scores, CAL scores, BOP were higher in the second study group with chronic periodontitisand coronary atherosclerosis than in the other groups with highly significant differences between the groups at(P≤0.01). Also by using Pearson Correlation Coefficient, salivary visfatin levels were correlated positively with allclinical periodontal parameters with a strong and positive correlation between salivary visfatin levels and CAL scoresand PPD scores. Salivary Creatine Kinase levels were correlated positively with all clinical periodontal parameters witha strong and positive correlation between its levels and mean values of GI and percentages of BOP.Conclusion: The present study showed that salivary visfatin can be used as a marker for the development ofcoronary atherosclerosis and its levels are associated with the degree of periodontal destruction and showed thatCreatine Kinase may be used as a marker for coronary atherosclerosis and chronic periodontitis.