Study the effect of supplementation of two types' of omega-3 poly

Abstract

AbstractAsthma is a chronic disorder ofthe airways with underlying inflammation and oxidative stress. Malondialdehyde(MDA) - the lipid peroxidation product- level increases in inflammatory diseases and used as a commonoxidative stress marker . Albumin and bilirubin, uric acid ; are components of antioxidant defense system.Omega-3polyunsaturated fatty acids supplementations lead to decrease the inflammatory mediators therebydecrease oxidative stress in asthmatics. Thirty seven asthmatic patients (20 females and l7 males) were involvedcompared with 37 healthy controls. Plasma samples analyzed for total MDA, albumin bilirubin, and uric acidbefore and after 3 weeks of supplementation of two types omega -3 polyunsaturated fatty acids (300mg/day) .After 3weeks of supplementation the MDA level change along supplementation period (p< 0.05), but it stillsignificantly differ fiom control (p<0.01), albumin and bilirubin retum to conhol level with non-significantdifference flom control, while uric acid increase significantly. These results indicate the decrease oxidative stresssituation since MDA levels decrease while endogenous antioxidant molecules (albumin, bilirubin , and uricacid) levels raised leading to conclude the valuable omega-3 fatty acids supplementation for asthmatic patients