Oro-facial manifestations, oxidative stress marker and antioxidant in serum and saliva of patients with Beta thalassemia major

Abstract

Background: Beta thalassemia is a typically autosomal recessive form of severe anemia which is caused by animbalance of two types of protein (alpha and beta) subunits of hemoglobin. Oxidative stress imbalance is theequilibrium between pro-oxidantantioxidant statuses in cellular system, which results in damaging the cells.Antioxidant is a chemical that delays the start or slows the rate of lipid oxidation reaction and it play a very importantrole in the body defense system against reactive oxygen species. The aims of this study were to recorded the orofacialmanifestations in beta thalassemic patients and assess the oxidative stress marker malondialdehyde in serumand salivs and their role in the pathogenesis of beta thalassemia and evaluation the antioxidant uric acid in serumand saliva of those patients.Methods: The study included fifty eight beta thalassemic major patients, twenty eight patients with periodontitis andthirty patients without periodontitis and twenty nine healthy subjects that were age matched with the patients. Orofacialmanifestations recorded clinically, serum and saliva malondialdehyde and uric acid were measured in allsubjects.Results : The main oro-facial manifestations were malocclusion ,rodent face, brown pigmentation of oral mucosaand incompetent lip.The mean serum and saliva malondialdehyde was significantly higher in thalassemic patientswith periodontitis (p<0.001). Serum and saliva uric acid was significantly higher in thalassemic patients withoutperiodontitis (p<0.001).Conclusions: Malocclusion was the most prevalent oro-facial manifestations in beta thalassemic patients, increasedserum and saliva malondialdehde refer to the role of oxidative stress in the pathogenesis of beta thalassemia. Uricacid increased to counteract the elevation in the oxidative stress process