Low Maternal Serum Vitamin D Level at Early Pregnancy and Subsequent Risk of Gestational Diabetes in Women with History of Previous Gestational Diabetes


background and Objective: GDM is a common condition during pregnancy which is associated with negative short-term and long-term outcomes both for mothers and offspring. Accumulating evidence links vitamin D deficiency with abnormal glucose metabolism. We performed this survey to investigate the predictive value of vitamin D deficiency as risk factor of GDM and, to evaluate the role of its replacement and incidence of development of GDM. Methods : Cohort study design was conducted in AL -Qadisia City .It included 60 pregnant women with previous history of GDM, and low level of vitamin D at this pregnancy which measured using enzyme immunoassay with cut- off point less than 20 ngml . FBS measured by photometric method .Then we divided the study population into : group1 include 30 women that given vitamin D from 16 weeks gestation till delivery. group2 include also 30 women who did not received vitamin . Result: In our study , low level of vitamin D (MS vitamin D was 11.65+3.23 ng/ml) and normal FBS at 14-16 weeks gestation, the mean age of women was(28.83 +6.03 years). After follow up: group 2 had significantly higher level of FBS than in group 1, 155.77+41.30 versus 110.10+36.86 (P<0.001), and the number and percentage of diabetic patients was also significantly greater in group2 than in group 1, n=22 ,73.33% versus n=6 ,20% (P<0.001).Conclusion: There is a statistically significant positive correlation between vitamin D deficiency and subsequent risk of GDM and in addition, vitamin D replacement significantly reduced the incidence of development of GDM in study population.