Identification of E-cadehrin Methylation in Iraqi Breast Cancer Patients

Abstract

E-cadherin (CDH1), a Ca++ dependent transmembrane glycoprotein functioning in cell to cell adhesion placed in 16q22.1, is one of the cardinal regulators of morphogenesis. Decreased levels of CDH1 expression related with the advanced stage and poorly differentiated cancers. This study involved detection of CDH1 methylation in breast tissue after surgery for breast cancer patints and control cases that involved cases of fibeoadenoma, benign breast tissue and normal breast tissue. The study revealed presence of CDH1 methylation in 93.3% of patients while the unmethylated control samples were 80%.