Effect of bisphenol-A- on reproductive system of female rats (Rattus Norvegicus)


Bisphenol-A-(BPA) is one of endocrine disruptor substances. The present study was conducted to investigate effect of BPA on reproductive system (reproductive hormones) such as Luteinizing hormone (LH), Follicle stimulating hormone(FSH) and Estradiol (E2)and (reproductive organs) such as ovary and uterus .Twenty four female rats were used and divided into three groups (8 animals for each group) randomly. Animals of first group was negative control group and second group was positive control group received normal saline and corn oil orally respectively, while female rat of third group were received BPA suspended with corn oil (250mg/kg B.W/day) orally as treatment group for 30 days. Results of the present study revealed significant increase (P≤0.05) in serum level of (LH, FSH, and E2) while histopathological changes in ovary include presence cyst-like structure and histopathological changes in uterus including increase in uterine luminal epithelial height and increase in number of uterine glands in the endometrium in group administrated BPA in compared with all other groups


bisphenol-A-, LH, FSH, rat