Assessment Of Diastolic Function In Diabetic Patients Using Conventional Echocardiogram & Tissue Doppler Imaging


Background: Left ventricular diastolic dysfunction (DD) is considered the first stage of diabetic cardiomyopathy; it occurs in absence of coronary artery disease, hypertension or valvular heart disease &can precede the systolic dysfunction in these patients.Objectives of the study: The purpose of this study is to assess the diastolic function in diabetic patients of both types 1&2 using conventional, Doppler echocardiograghy and tissue Doppler imaging, and to reveal the impact of age, gender & duration of diabetes on prevalence and grading of DD.Patients and methods: This is an observational case control analytic study in which 100 persons were enrolled, 50 of them were diabetic patients, and the other 50 were age, sex matched healthy control subjects. In both groups` systolic and diastolic functions were assessed by conventional, Doppler and tissue Doppler echocardiography. Results: Among the 50 patients, 27 (54%) of them were females and 23 (46%) were males, 27 (54%) of them were type1 diabetes and 23(46%) were type2 diabetes. Control group consisted of 50 subjects including 24(48%) females and 26(52%) males. Patient’s age ranges from 15 to 70 years with mean age (39±16.09), control subject’s age ranges from 15 to 72 years with mean age (37.64±14.53).There was significant relationship between aging and prevalence of DD (P value=0.02).Gender not related to prevalence of diastolic dysfunction. There was significant decrease in E/A ratio between both groups (P value=0.0007), while E/É ratio between both groups was not significant. DD also was higher in type2 diabetes compared with type1 (P value<0.001).Diabetic duration has no impact on prevalence of DD.Conclusion: Diabetic patients have significant DD detected on both conventional and tissue Doppler echocardiography. Diastolic function is affected with increasing age, but not with gender. The diabetic cardiac changes as well as the echocardiographic parameters seem not to be affected with diabetic duration.