A study of the Biochemical and Haematological parameters in Patients of Typhoid Fever

Abstract

Many studies have indicated several biochemical and/ or haematological parameters that are involved in developing the risk of typhoid fever such as hepatic dysfunction, central nervous system complications, cardiovascular complications, leucopenia and neutrophils leukocytosis. The aim of this study was to evaluate the relation between biochemical and haematological parameters. Total 47 subjects were studied, 19 healthy individuals and 28 typhoid patients (aged 15-60 years old). Levels of Monocyte, Lymphocytes, total White Blood Cells (WBC), Haemoglobin concentration (Hb), Packed Cell Volume (PCV), Platelet count (PLT), Red Blood Cells (RBC), Uric acid, total Serum Bilirubin (TSB) , Blood Urea (B.Urea) and serum enzyme activity: Aspartate transaminase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP) and Creatine Kinase (CK). Results showed that ALT, AST, ALP, TSB, S.Uric acid, B.Urea and RBC were higher in patients compared with control while CK, Hb, PCV, WBC, Monocyte, Lymphocyte and PLT were lower in patients compared with control. Conclusion: correlation between haematological and biochemical parameters could be afford and thereby serves as indications for more reliable and diagnosis aid of the infection with typhoid fever which could changes the necessary antibiotic therapy .