Evaluation Serum Gamma-Aminobutyric Acid (Gaba) Receptor Levels In Autistic Children And Correlated With Behavior


Autism is described by impaired functioning on three behavior domains: qualitative impairments in social interaction, qualitative impairments in communication, and the occurrence of stereotyped behaviors or restricted interests. Experimental evidence of GABAergic mechanism in Autistic Disorders is limited. Few reports have demonstrated abnormalities involving the GABA receptor in the brain, blood, and platelets of subjects with autism in compared to nonautistics. Serum from 50 individuals with autism (36 males, 14 females;, mean age 7.80 years) and 25 non-autistic group (21 males, 4 females; mean age 8.46years) was assessed for GABA receptor concentration using ELISAs. Personality ,severity, language and ability to learning) was assessed in these autistic individuals and compared with GABA receptor. In this novel study, individuals with Autistic had significantly significant decrease serum level of GABA (p < 0.05) (33.10±5.12 ng/ml) compared with the healthy control (144.04±9 ng/ml). In addition, the negative correlation was found between low GABA receptor levels and speaking, learning, symptoms severity. While positive correlation between low GABA receptor levels and personality among autistic patients. These results concluded correlation between GABA and Autism.