THE EFFECT OF GALLIC ACID AS PROTECTIVE AGENT ON SOME BIOCHEMICAL PARAMETERS INDUCED HYPERCHOLESTEROLEMIA IN LABORATORY MALE RATS

Abstract

The role of gallic acid was studied to alleviating some biochemical parametersalterations in hyper cholesterolemia in rats. For this purpose 24 sexually adult malerats were divided randomly in to 4 groups (6 rats each). The experiment wasconducted at the animal house of the Veterinary Medicine College–University ofBasrah, the control group, rats were injected intraperitoneally ( I.P.) with 0.9 %normal saline (N.S)and were supply with the stander ration.The first treated group were injected intraperitoneally ( I.P.) with 100 mg/ kggallic acid dissolve in 0.5 ml distilled water daily and were supply with the standerration.The second treated group were supplied with the stander ration in addition to1.5% cholesterol of the stander ration .The third treated group were supplied with standard ration in addition to1.5% cholesterol, and injected intraperitoneally ( I.P.) after one hour with 100 mg/kggallic acid dissolved in 0.5 ml distilled waterThe obtained results indicated that the administration gallic acid as protectiveagent on high cholesterol diet tend to alleviated and improved lipid profile by asignificant reduction in the serum total cholesterol(TC),LDL-C and VLDL compared with animals fed cholesterol 1,5% diet, hepaticenzymes activates of AST &ALT in the protective group almost were at the range ofnormal values and the protective urea blood value reach almost as the normal level ascontrol group.