Impact Of Hypoxemia In Patient With Chronic Obstructive Pulmonary Disease On Renal Function Tests


Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases and is expected to be progressively increasing. There are many co-morbidities associated with it, but the relation between it and changes in renal function tests is still unclear. The aim of this work was to illustrate the extent of kidney dysfunction in patients who suffer from COPD. This study was performed in Merjan Medical City, the period of study was from November 2013 to June 2014, it included 86 patients with COPD and 70 control healthy subjects who completed medical questionnaires, pulmonary function tests and measurement of blood urea and serum creatinine. The data was statistically analyzed, the level of statistical significance that was depended for this study was P values ≤0.05. The results of this study revealed significant difference in the mean values of blood urea (Bur), serum creatinine (Scr), and creatinine clearance (Ccr) before and after treatment for all patients, Bur increased and Ccr decreased significantly in hypoxic group in comparison with non hypoxic group (P ˂ 0.05); while no significant changes in Scr (P = 0.1). In addition, the study showed a significant correlation between blood urea and creatinine clearance (Ccr) with SPO2 (before treatment) (p < 0.05), while non-significant negative correlation between serum creatinine and SPO2 (before treatment) (r = 0.1, P > 0.05).The results illustrated that the Bur and Scr increased; while Ccr decreased significantly in male group in comparison to female group (P˂0.05). Also there was no significant correlation between blood urea, serum creatinine, and creatinine clearance with forced expiratory volume in first second (FEV1) (before treatment) (P > 0.05). From this study, we conclude that abnormalities of renal function tests are common in patients with COPD at the first days of admission to hospital.