Assessment the Association between Anti-Chlamydial Ab in Coronary Heart Disease with Some Immunological Parameters in Diyala Province

Abstract

This study was conducted in Diyala province for patients with Coronary heart diseases during period from the beginning of August 2015 to the end of May 2016, and the study was aimed to determine the relationship between Coronary heart diseases and Chlamydia pneumonia and to evaluate some immunological indicators for patients with coronary heart diseases, which included the rate of anti- Ch. pneumoniaeIgG and IgM antibodies among patients with coronary heart diseases and determining the level of interleukin-6 (IL-6) and interferon gamma (IFN-Y ) mediated by ELISA. A total of 140 for patients with coronary heart diseases where 95 males and 45 of the female after diagnosis by a physician specialist in advisory clinic in Baquba Teaching Hospital in Diyala province, according to the criteria adopted by the World Health Organization , also collected 30 sample as a control group contain 16 male and 4 of the female. The mean age of patients 53.42 ± 13.87years with an age rang 31-70 years, and for the controls, and the mean age was72.85 ± 14.92 years. The results of the current study showed that male patients are higher than females 34.2% 13.4%, respectively, with a statistically significant difference. The result recorded that age group 31-50, 51-70 years had the highest rate of infection by 20% and 56.42%, respectively, and the lowest percentage of infection within the age group 10-30, 70> years and by 4.28% and 19.28%, respectively and with statistically significant difference .In addition, the result of this study recorded a high positive rate of anti- Ch. pneumoniaeIgM and IgG antibodies in patients group than control group, there were, the positivity of anti- Ch.Pneumonia IgM and IgG antibodies in patients group was 6.42% and 50.7% respectively , while in control group was 0% for two types. The results also showed a significant increase in the concentration of IL-6 in the serum of patient compared with healthy sample, reaching concentration in the blood of people with CHD was750.5±146.8 pg / ml, while the concentration in the standard sample was 227.8±17.6 pg / mL. The results showed a significant increase in the concentration of INF-Ƴ in the serum of patient compared with healthy sample, reaching concentration in the blood of people with CHD was 941.6±143.1 pg / ml, while the concentration in the standard sample was 376.5±56.09 pg / mL .