The Decrement of Glutathione Peroxidase Activity Associated with the Elevated Diene Hydroperoxide Levels in Serum of Patients with Diabetes Mellitus Type I

Abstract

The glutathione peroxidase, vitamin E and dienhydroperoxide in serum were investigated in 30 subject with Type 1 (insulin-dependent) diabetes mellitus and in 30 healthy others. The mean conjugated hydroperoxide(CDH) value in the serum of diabetic patients were significantly higher than those in the control subjects (conjugated dienhydroperoxide p<0.01). The Glutathione peroxidase activity and the levels of Vitamin E significantly decreased(GPx p<0.05 while Vitamin E p<0.01). These data suggest that hyperglycemia induces oxidative stress in sera of patients compared with healthy controls and that antioxidants which used in the study are effective against oxidative injury.