Correlation between Obesity and Semen Interleukin-6 with Sperm Concentration and Motility in Iraqi infertile Men


BackgroundObesity has been defined as abnormal or excessive fat accumulation that may impair health while the Body mass index (BMI) is a simple index of the weight-to-height ratio that is commonly used in classifying overweight and obesity in adult populations. Many semen parameters alteration can be ascribed to obesity like decreased sperm concentration , abnormal morphology, compromised chromatin integrity and abnormal motility. Many evidences showed an adverse effect of excess body fat on spermatogenesis.MethodsA total sample size composed of (?O)infertile men were grouped into three groups according to published BMI ranges as follows: normal weight, overweight and obese .A single semen sample was collected for each infertile men.Heightin (m) and weight in (kg) were recorded on day of semen collection .BMI was calculated as BMI= Kgm2. Sperm parameters evaluated accordingto World Health Organization guidelines.Quantitation of the IL-6 inseminal plasma were accomplished using commercially available ELISA kit.ResultsIn the current study, a positive correlation was found between body mass index and IL-6, on the contrary, a significant negative correlation was found among IL-6 level and progressive sperm motility and sperm concentrat ion as well.ConclusionThere is an increase of IL-6 from the adipose tissue with increasing BMI. The IL-6 cause reduction of the sperm motility by increasing the level of ROS. The obesity reduces the spermatogenesis by androgenic deficiency results in low sperm concentration and motilitywhich it may bethe main reason of their infertility.The aim of the study: to evaluate the correlation between the obesity and IL-6 and their effects on sperm concentration and motility.