Assessment of Omentin-1 as a predictor and Renoprotective for type 2 Diabetic Nephropathy

Abstract

Background: Diabetic nephropathy is one of the most serious microvascular complications of diabetes, which may lead to chronic kidney disease in diabetic patients.Objective: to explore correlation of omentin-1 and diabetic nephropathy in type 2 diabetic patients.Method: Serum omentin-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 61 type 2 diabetic patients. These patients were classified into two groups according to their albumin/creatinine ratio (ACR), into patients with normoalbuminuria, group C (ACR< 30 mg/mmol), patients with microalbuminuria, group B (ACR=30-300 mg/mmol), twenty five (25) (10 male and15 female) apparently healthy matching the Pearson were selected as a control group (group A).In addition, glucose and lipid profile and morphological characters were assessed.Result: The serum OMT level of group B was much lower than those of group C and group A. While, there was non-difference in OMT level between group C and group A.Conclusion: Detection of serum OMT level may play an important role in early diagnosis and prevention of diabetic nephropathy in T2DM.