Changes in serum potassium and serum creatinine in hypertensive patients treated with Captopril with or without amlodipine

Abstract

Background. Renal function and serum potassium are affected by many drugs.Angiotensin Converting Enzyme inhibitors and calcium channel blockers used to treathypertension and non steroidal anti-inflammatory drugs used for musculoskeletaldiseases. Those drugs affect both the renal function and the serum potassium. The aimof this study was to find the impact of these drugs on the renal function and serumpotassium.Methods. A prospective study includes 60 patients in Al Hussain Teaching hospitalin Kerbala. Sixty patients were involved in this study 27 male and 33 female, theirage ranges between 41 and 65 years with a mean age of 52.98 years.All patients had hypertension and 34 of them had diabetes mellitus also. All patientsstarted on captopril, 13 of them amlodipine added for them to control blood pressure,and 11 used none steroidal anti-inflammatory drugs. Serum potassium and serumcreatinine were checked twice before starting treatment and the average valuerecorded and checked again after 3 months. Physical examination was done duringthe follow-up visits to look for symptoms and signs of hyperkalemia e.g. weakness,fatigability, parasthesia, or areflexia. Electrographic recording done to look forchanges of hyperkalemia.Results.A significant increase in serum potassium and creatinine after starting treatment inthe whole group. Regard the gender there were significant differences in both theserum potassium and serum creatinine in female patients but the differences were notsignificant in male patients.There was a significant difference in serum potassium in patients receiving captoprilalone but not in serum Creatinine. There was difference in serum potassium andserum creatinine in the group of patients receiving captopril and amlodipine andstatistically were significant. Changes were significant in diabetic patients but not inhypertensive patients.Conclusion. Captopril, amlodipine result in an increase in serum potassium and inserum creatinine in patients treated for hypertension.