Synthesis and characterization of some new N-mannich bases for clonazepam


The N- Mannich bases (1-10) have been synthesized by reaction of clonazepam withformaldehyde or benzaldehyde and different secondary amines. The N-Mannich baseswere subjected to physicochemical studies like melting point determination, TLC andyield%. The structures of mannich bases were characterized by IR, 1HNMR and13CNMR spectroscopy.