The Effect of Carrageenan on Lymphoma Patients under Chemotherapy (A case series study)

Abstract

Background There are three types of carrageenan available (iota, kappa, and lambda) which differ in composition and degree of sulfation in polymeric structure. A malignant lymphocytes that accumulate in lymph nodes causes a group of diseases called Lymphomas causing the characteristics lymphadenopathy. These may pelt over into the blood or infltrate organs outside the lymphoid tissue. They are Hodgkin›s lymphoma and non–Hodgkin›s lymphoma and this is based on the histologic presence of Reed-Sternberg cells in Hodgkin›s lymphoma. Objectives The present study designated to determine the oral manifestations after application of carrageenan in patients with Hodgkin›s& Non-Hodgkin›s lymphoma receiving chemotherapy and to determine the effect of topical carrageenan on the levels of salivary immunoglobulin A, interleuekin-6 and tumor necrosis factor-α in Hodgkin›s & non-Hodgkin›s lymphoma patients. Results The oral manifestations was in Non-Hodgkin›s lymphoma patients (64%) and in Hodgkin›s lymphoma patients (36%) taste alteration, followed by burning mouth syndrome, dry mouth and lastly candidiasis with signifcant differences after application of carrageenan p>0.05.The levels of salivary immunoglobulin A, interleuekin-6 and tumor necrosis factor-α were slightly decreased but not signifcantly differences after carrageenan application. Conclusions The carrageenan effects on oral lesion may allow the use of Κ –carrageenan as a base or primary compound in dental practice besides the other compounds like chlorhexidine. The salivary immunological markers level slightly decreased in lymphoma patients after receiving carrageenan which indicate that there is no absorption from oral mucosa.