Protective Role Of Curcumin On some of oxidative stress parameters and cerebrum Tissue In Male Rabbits Subjected To Monosodium Glutamate

Abstract

This study aimed to know the preventive role of a substance Curcumin . against damage happening in the nervous system and induced textured monosodium glutamate (MSG) in male rabbits., sixty of adult male rabbits were randomly divided into four equal groups (15 animals / group), the first group (G1) intubated with 1 ml / kg ml / kg of corn oil and served as a control group (G1). The second group were intubated orally and daily with 3mg /kg of MSG for three months , while the third group (G3) has intubated orally and daily with 60 mg / kg curcumin for three months , the fourth group intubated orally and daily with 3mg /kg of MSG and 60 mg / kg of curcumin for three months .Fasting blood samples were collected from fasted rabbits at pretreated period , Mid-experiment and at the end of experiment to study the following parameters: concentration of Malondialdehyde (MDA) , Reduced Glutathion (GSH) and peroxy nitrite ( ONOO ( _ . The results revealed that oral dosing with MSG caused a significant decrease (P <0.01)in rate of GSH compared with control group and significant increase (P < 0.01) in rate of MDA , ONOO _ compared with the control group. The group that treated with 60mg/kg curcumin revealed a significant increase (P <0.01) in GSH concentration compared with the control group and a significant decrease (P <0.01) in the concentration MDA and ONOO _ compared with the control group. Experience also shows that oral dosing with MSG and curcumin caused no significant difference(P <0.01) was observed in the concentration GSH ,MDA and ONOO _ compared with the control group.