Leptin, Obesity and IgE in patients with Asthma and Allergic Rhinitis

Abstract

Background: Asthma is a chronic inflammatory disease of the respiratory airways with a worldwide prevalence. This study was performed to evaluate the role of leptin on asthma and /or allergic rhinitis, and to study asthma-obesity-leptin relationship. Methods: A cross sectional study was performed on asthmatic patients (190), allergic rhinitis patients (110) and healthy control subjects (48). Results: Serum leptin was significantly higher at asthma with overweight, asthma with metabolic syndrome, allergic rhinitis with overweight patients than of control subjects, while it was of no significant statistical difference at asthma with normal weight, allergic rhinitis with normal weight patients than of healthy control individuals. Body mass index was significantly higher in asthma with overweight patients; asthma with metabolic syndrome and allergic rhinitis with overweight. It was of no significant difference in asthmatic with normal weight patients, allergic rhinitis with normal weight than of control subjects. FEV1 was significantly lower in asthma with normal weight patientss; asthma with overweight; asthma with metabolic syndrome; allergic rhinitis with normal weight; allergic rhinitis with over weight than in control subjects. Conclusion: Leptin was significantly higher in patients with asthma and allergic rhinitis as compared to healthy non allergic individuals and it was influenced by BMI and presence of metabolic syndrome in allergic patients. BMI influence FEV 1 in both asthmatic and allergic rhinitis patients.