Prophylactic Versus Extended Antibiotics Regimen in Breast Cancer Surgery


Background: A single intravenous preoperative prophylactic dose of an antibiotic with antistaphylococcal activity represent standard care for breast and axillary surgical procedures. Some surgeons also prescribe postoperative extended regimen for all patients with breast and axillary surgery to prevent infection.Objective: To evaluate the efficacy of using post-operative antibiotic (extended regimen)in breast cancer surgery to decrease surgical-site infections.Patients and Methods: One hundred and five females suffering from breast cancer were enrolled in this study (from the 1st of January 2014 to the 30th of December 2015 inAl-Yarmouk Teaching Hospital admitted by multiple surgeons).They was divided into two groups. Group )1( received single prophylactic dose of ceftriaxone injection 1gm preoperatively and group )2( received extended doses postoperatively1 gram twice daily for 4days,then antibiotic changed to oral oute (cefixime 400 mg once daily for 7days). The patients in both groups discharged home in the2nd post-operative day and seen again after five days, then on the days, then on the day of removal of surgicalstitches (day10) and at day30.Allpatientshadclosedsuctionsurgicaldrainswhendischargedfromhospitalandremoved inday5. Second generation cephalosporin was not used because it is not available.Results: During the period of this study, the incidence of wound infection was 7 (15%) in group1 and 6 (10%) in group2. The p value of the incidence of wound infection in these groups was 0.55, so it is statistically not significant.Conclusion: No statistically significant reduction in surgical wound infection among those received postoperative extended doses of antibiotic prophylaxis (i.e.group2) compared with those who received preoperative single dose of antibiotic prophylaxis (i.e.group1) .