Risk Factors and Early Detection of Diabetes Mellitus in Early Rheumatoid Arthritis Women


Background: Patients with rheumatoid arthritis show predominance of metabolic disorder characterized by overweight, central obesity, dyslipidemia and impaired glucose tolerance, specifically, few studies have explain insulin resistance in this disease.Objective: The aim of present study is to examine insulin resistance and the risk of developing diabetes mellitus in middle age Iraqi women with early rheumatoid arthritis.Patients and methods: This work involved seventy female with early rheumatoid arthritis. Who was attending to the National Diabetic Center (NDC) of Al-Mustansiriya University and 35 healthy subjects as a control group. From all subjects blood sample was drawn in fasting state to measure the biochemical parameters which including plasma glucose level and fasting insulin concentrations. Other measurements (RF and anti-CCP) were made by routine methods. Homeostasis model of assessment insulin resistance (HOMA-IR) by using the formula HOMA model Insulin sensitivity was calculated in RA patients and healthy control.Results: Results revealed a highly significant in the level of rheumatoid factor (RF), anti-CCP and fasting insulin, and HOMA-IR when compared patient group with control group. While a significant increase in level of FBG in RA group than control group. Also there was a positive correlation with high significance among, Anti-CCP, and RF with HOMA-IR in rheumatoid arthritis group. Conclusions: This study shows that patient with rheumatoid arthritis have abnormal insulin secretion with high value of IR than group of healthy control and these patients may be at risk of diabetic mellitus.Keywords: Rheumatoid arthritis, RF, anti-CCP, insulin resistance