6-OVERDOSEOF TUSSIRUM INDUCED HISTOPATHOLOGICAL CHANGES OF THE LIVER AND KIDNEY IN MALE DOMASTIC RABBITS

Abstract

In this study, the histopathological changes due to overdose usage of Tussirumdrug(0.75 and 3 ml/Kg)in liver and kidney were assessed in rabbite with lightmicroscopes. Six male rabbites(1 ± 0.5 Kg ) were included and divided into threegroups.Normal saline (3ml/Kg) wasgiven orally as placebo in the control groupI (N= 2).Group II and III(N= 4 for each) was received Tussirum orallyat a single dose of (0.75 and3ml/kg/day) for 30 days respectively. the results were recorded that both doses ofTossirum were induced that blood vessel congestion, aggregation of Kuppfercells,inflamintion infiltrations and Sinusoidal dilatation in the liver parenchyma inaddition to the cytoplasmic vacuolation, degeneration, pyknotic nuclei in the hepatocytesand. On the other hand, renal damage was observed in the kidneys of treated rabbits,necrosis of glomular, degeneration of nucli and degeneration in the lining epithelial cellsof renal, also noted that glomular shrinkage, dilated of reanal tubules and hyperplasia oftubles walls,as well as to necrosis of renal tubules endothelium, closing of renal tubuleslumen, isulation of renal tubules endothelium and density in some nucli chromaticFinally, the investigators concluded that Tossirum toxicity induced hepatocellular andrenal damage