Effects of Extracted Phenolic Compounds from Grape Seeds on Leptin, Adiponectin and Resistin Levels in Rats Fed with High Fat Foods


The current study was constructed to evaluate the efficacy of grape seed extracts (GSE) in management of obesity induced by high fat diet (HFD)-induced obesity in rats through assessment of the serum leptin, adiponectin, and resistin. Experimental rats were divided into three groups: G:1 (healthy control), G:2 (obese control), G:3 (received100 mg/kg of GSE), after 7 weeks, serum leptin, adiponectin, and resistin levels were measured in all groups. Results in present study showed a significant (P<0.01) increase of serum leptin, and resistin levels in obese rats G2 in comparison to the control healthy rats G1 (39.35±1.07 vs 7.48±0.6), (48.84±3.73 vs 31.43 ± 2.02) respectively. The level of serum leptin, and resistin in obese rats decreased significantly in G3 (P < 0.01) when received GSE 100 mg/kg body weight for 7 weeks in regard to G2 (30.46 ± 0.93 vs 39.35 ± 1.07), (42.23±1.21vs48.84±3.73), whereas significant decrease in serum adiponectin level in obese rats G2 to G1 (4.8793 ± 0.5040 vs 9.245± 0.8794). After treatment with 100 mg/kg GSE, the level of adiponectin decresed in G3 compared with G2 (6.1220 ±0.6330 vs 4.8793± 0.5040).Conclusions: The results show that, the phenolic extracts of grape seed could reduce serum leptin, and resistin levels and increase adiponectin in HFD induced obesity in rats