A Comparative Estimation of Metabolic and Hormonal Parameters Among Iraqi Hypothyroid Patients


ABSTRACT:BACKGROUND: Thyroid hormones have a crucial physiological role to maintain balance of metabolism of body. Deficiency of iron can produce hypothyroidism. Hypothyroidism causes several lipid metabolism disorders. Visfatin and leptin are adipocytokines and have been suggested as important regulators in patients with thyroid dysfunction.OBJECTIVE: The aim of the present study was to estimate the circulating levels of lipids, iron, visfatin, and leptin in newly diagnosed hypothyroid patients. PATIENTS AND METHODS: The current study was conducted in medical city teaching hospital on 45 newly diagnosed cases of hypothyroidism aged 35-50 years and compared with 45 healthy in¬dividuals as control group during the period from June 2016 to January 2017. This study investigated the serum concentrations of lipid profile, some iron status parameters and hematological parameters, total- and free-, triiodothyronine, tetraiodothyronine, thyroid stimulating hormone, visfatin, and leptin in hypothyroid patients and compared them with the controls.RESULTS: There was a significant increased in serum total cholesterol and triacylglycerol in hypothyroid patients compared to the control, (P=0.001). There was a significant decreased in hemoglobin, serum iron, and ferritin while a significant increased in total iron binding capacity in hypothyroid patients compared to the control, (P≤0.05). Means value of thyroid stimulating hormone levels were significantly increased in hypothyroid patients compared to the control group. On the other hand, the levels of total- and free-, tetraiodothyronine, free triiodothyronine were significantly decreased in hypothyroid patients as compared to the control group. There was a significant increased in visfatin and leptin concentrations in hypothyroid patients compared to the control group, (P≤0.05).CONCLUSION: These data suggest that thyroid hormone insufficiency may lead to deficiency of iron and lipids abnormalities. Thus, estimation of iron and related parameters with lipids may be quite useful during the diagnosis and treatment of hypothyroid patients. Also, alterations in thyroid status change serum visfatin and leptin in hypothyroid patients. It is advisable to routinely investigate them for early detection allowing its early management.