The protective and therapeutic effect of alcoholic extract of rosemary officinalis against degeneration effect of over dose of paracetamol on the heart muscle of rats.


The experiment were performed in present study to estimate the protective and the therapeutic role ofethanolic extract of rosemary (Rosmarinus officinalies) leaves against acute destructive changes in ratsdue to high dose of paracetamol, 1ml/ 1000mg/ kg that led to a particular aspect of heart necrosis,congestion, vacuolation of heart muscle cells, and infiltration of inflammatory cells. Leaves and stem of(Rosemary officinalies) were collected, identified, dried, powdered and extracted by using 90% ethanol insoxhlet apparatus. Twenty healthy albino mature male rat’s Rattus norvegicus were used in this studywere divided to four groups, including group1 (control group) group 2 were given over-dose ofparacetamol for 3 weeks, group 3 were given combination consist from high dose of paracetamol andalcoholic extract of (Rosemary officinalies) for 6 weeks, and group 4 were given rosemary extract for 3weeks after it was given over-dose of paracetamol for 3 weeks. The histopathological result showed thatthe alcoholic extract of rosemary officinalis have the protection effect when used in combination withhigh dose of paracetamol that clear in microscopic appearance of the heart muscle in group 3, while thehistopathological result of group 4 revealed the therapeutic effect to the alcoholic extract of rosemaryofficinalis and the microscopic appearance showed the intact heart muscle. The present study revealed theproductive and treated role to alcoholic extract of rosemary officinalis on heart muscle after long term ofoverdose of paracetamol that showed degeneration and vacuolation in muscle fiber addition thatinfiltration of inflammatory cell, the extract of this plant resolve the pad tissue changes on the heart tissueespecially in group 4 that appear intact heart muscle and in group 3 showed reduce the sign of theoverdose.