Role of Innate Immune Response Components in the Osteoarthritis

Abstract

Background:Osteoarthritis is a progressive joint disease is mainly worrying on weight bearing in the body, the joints, particularly the knee and hips. Osteoarthritis as an inflammation in the joints must there is an immune defense in the body against this inflammation. This disease that appears primarily in the elderly characterized by erosion articular cartilage, osteophyte, subchondral bone stiffness, synovitis inflammation, many causes of the disease such as age, sex, and obesity, the location of the joint injury and various other factors.Objective:To understand the role of innate immune response components in the osteoarthritis, this study was investigated the relation between the innate immune response and osteoarthritis.Patients and Methods:Fifty osteoarthritis patients and fifty healthy persons were participate in this case-control study. The total WBC count, neutrophil percent, lymphocyte percent, monocyte percent, eosinophil percent, basophile percent, platelet number, level of ESR, Level of CRP, and level of C3 complement were investigate in serum and synovial fluid in the osteoarthritis patients and control healthy persons. Results: The results were shown significant elevation in the WBC count, platelet number, level of ESR, level of CRP and level of C3 complement in the serum of osteoarthritis patients compared with control group. A significant positive correlation was shown with weight of patient and the severity of osteoarthritis. The elevation level of C3 complement in the synovial fluid was a significant positive correlation with elevation of level of C3, level of ESR, level of CRP, and WBC count in the serum of patients related to the severity of osteoarthritis status.Conclusion:The results were given an evidence for the crucial role of innate immune response in the defense against osteoarthritis inflammation and any defect in the innate immune component lead to increase the severity of osteoarthritis.